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What can you do to support the person in your life TTC (Trying to Conceive)

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Chances are Trying to Conceive, you know someone who is struggling with infertility. More than seven million people of childbearing age in the United States experience infertility. 

– Be Supportive: Simply listen and be ready to listen when called upon.⁠

-Acknowledge infertility as a medical and emotional crisis with a wide variety of losses, disappointments, and ‘costs’: physical, financial, social, marital. ⁠

-Be sensitive to the pain, stress, and emotional pressure of childlessness or the inability to expand one’s family as desired.⁠

-Respect the boundaries the infertile individual or couple sets regarding their infertility TTC (Trying To Conceive). Some infertile people prefer a high level of privacy about infertility. Others choose a more open approach.

  • Realize that no matter what they are going through, no matter where they are on the fertility journey— they are strong.⁠ 

⁠”Sometimes courage isn’t climbing Mount Everest or changing the world. Sometimes your mountain to climb is made up of weekdays and months, made up of pushing yourself forward even when you want to nestle into the past. Sometimes changing the world means changing your world as gradually as you need to, as gently as you heal, because sometimes courage isn’t made up of war and bloodshed; sometimes courage isn’t made of combat. Sometimes courage is a quiet fight, a dim softness within you, that flickers even on your darkest days and reminds you that you are strong, that you are growing—that there is hope.”⁠

Are you struggling with the question “To Embryo Biopsy or NOT?” ⁠

Preimplantation Genetic Testing (also known as PGT-A, CCS, or PGS) is a diagnostic tool to tell your fertility doctor which embryos are likely to be chromosomally normal and therefore, which to transfer.⁠

As women age, the chance of a chromosomally normal embryo declines. Underage 30, roughly half of the embryos will be normal, and most young women find multiple euploid embryos after testing. Overage 40, 1/3 to 1/2 of all women will not find a viable embryo after PGT-A.⁠

Euploid embryos are most likely to lead to living birth and should be transferred first. Embryos that are mosaic can still lead to living birth, but depending upon the type, do so less often, and carry some risk. Embryos that are aneuploid almost never lead to live birth and if they do, carry a major risk the child will be unhealthy.⁠

PGT typically costs $5,000 can help to avoid:⁠

-FailedFET (each costs $3,000 to the patient)⁠

-Miscarriages (each cost $5,000 to the insurer, which pales in comparison to the emotional pain they cause patients)⁠

-Multiple gestation births from transferring back more than one embryo (twin deliveries cost $100,000 and triplet deliveries cost $500,000)⁠

We can perform up to three types of preimplantation genetic testing on embryos during the IVF process. Those include:⁠

PGT-A, which screens for an abnormal number of chromosomes.⁠

PGT–M is the test for individual, or monogenic, diseases.⁠

PGT-SR tests for abnormal chromosomal structural rearrangements, like translocation or inversion.⁠

⁠PGT begins with a biopsy of an embryo in the blastocyst stage of development, usually on day 5 or 6 of embryo development. The biopsy removes 3 to 10 cells from the trophectoderm, which is the outer layer of cells that will become the placenta as the embryo develops. The biopsy does not remove any cells from the inner cell mass, which develops into the fetus.⁠

After these cells are removed, the blastocyst is frozen and stored in the lab.⁠

The biopsied cells are sent for laboratory testing. Results are typically returned in a week to 10 days following the biopsy.⁠

Miscarriage with PGT Normal Embryos 

Have you experienced a miscarriage with a PGT normal embryo? ⁠

Genetics, while an incredibly important indicator of embryo health, are only one piece of the IVF puzzle.⁠

Many factors contribute to whether an embryo becomes a healthy baby or not, and even transferring a euploid embryo is not a guarantee that you will get (and stay) pregnant (conceive), though it does significantly increase your odds. ⁠

For those new to the terminology, PGT is a genetic test that takes place before embryo transfer, designed to tell you if each embryo is chromosomally healthy. An embryo that is euploid (normal) has 23 pairs of chromosomes and has a better chance to conceive at leading to a successful live-birth than an abnormal (aneuploid) embryo. Aneuploid embryos have missing or extra chromosomes and will typically fail to implant, result in a miscarriage, or lead to the birth of a child with a chromosomal disease.

Besides the two possible PGT results we’ve already talked about– euploid and aneuploid– there’s also another: mosaic. A mosaic embryo consists of both euploid and aneuploid cells. While mosaicism has existed all along, PGS testing has only been able to recognize mosaicism in embryos within the past three years, so there is still a lot of research ongoing about their potential. What we know now is that about 10-15% of all embryos are mosaic.⁠

You must go to clinic for checkup to conceive for healthy baby.